Pulling SEC filings + quote and writing the call…
Pulling SEC filings + quote and writing the call…

Spero Therapeutics, Inc.
Next earnings Aug 10, 2026 · consensus $-0.17 EPS
Last earnings -3.9% on 2026-05-13
Revenue grew 3292.5% YoY.
Quality fundamentals and an attractive price line up (~158% below fair value) — the rarer case where both the business and the entry look good.
Sources: SEC EDGAR (CIK 0001701108, latest 10-Q filed 2026-05-13) · EODHD · as of 6/23/2026, 2:46:47 AM.
Research and education only — not financial advice. Calls are generated from SEC filings and a delayed/third-party price feed, may be wrong or out of date, and are not a recommendation to buy or sell any security. Do your own research.
Spero Therapeutics, Inc. shows $12.6M in FY2025 revenue (+3292.5% YoY), a 68.1% net margin, and 14.5% ROE.
The risks, catalysts, 12-month price target and the cited SEC figures behind this rating — with Pro.
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| Line item | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Revenue | $3.07M | $2.50M | $933K | $371K | $12.6M |
| Gross profit | — | — | — | — | — |
| Operating income | -$88.0M | -$42.2M | $21.5M | -$73.4M | $6.31M |
| Net income | -$89.8M | — | $22.8M | -$68.6M | $8.57M |
| Diluted EPS | -$2.91 | -$1.23 | $0.43 | -$1.27 | $0.15 |
| Net margin | -2925.1% | — | 2444.4% | -18481.4% | 68.1% |
Annual figures from SEC 10-K XBRL filings. Open the filing links below for full statement detail.
Computed from SEC XBRL annual figures + the current quote. EV and ROIC use long-term + current debt where filed; estimates, not investment advice.
1483 tracked peers · median
Dates from 8-K (Item 2.02); beat/miss = reported EPS vs consensus (Finnhub, recent quarters); move = prior close → close on/after.
Last 90 days: 0 open-market buys · 1 sale
| 2026-05-04 | Rajavelu Esther See Remarks | Sell | 25.2K @ $2.51 | $63.4K |
| 2026-02-06 | Rajavelu Esther See Remarks | Sell | 37.1K @ $2.36 | $87.6K |
| 2026-02-06 | Rajavelu Esther See Remarks | Sell | 50.8K @ $2.36 | $120K |
| 2026-02-06 | Keutzer Timothy Chief Operating Officer | Sell | 18.7K @ $2.36 | $44.0K |
| 2026-02-04 | Keutzer Timothy Chief Operating Officer | Sell | 3.47K @ $2.24 | $7.78K |
| 2026-02-03 | Keutzer Timothy Chief Operating Officer | Sell | 24.2K @ $2.14 | $51.8K |
| 2026-02-02 | Keutzer Timothy Chief Operating Officer | Award | 68.0K | |
| 2026-02-02 | Keutzer Timothy Chief Operating Officer | Sell | 18.9K @ $2.20 | $41.6K |
| 2026-02-02 | Rajavelu Esther See Remarks | Award | 249K | |
| 2026-02-02 | Rajavelu Esther See Remarks | Sell | 18.4K @ $2.20 | $40.6K |
| 2025-11-07 | Rajavelu Esther See Remarks | Sell | 40.3K @ $2.37 | $95.4K |
| 2025-08-28 | Mahadevia Ankit Director | Sell | 6.57K @ $1.97 | $12.9K |
Recent news tone vs the market's typical (which skews positive). A soft signal, not a recommendation.