Pulling SEC filings + quote and writing the call…

Maze Therapeutics, Inc.
Next earnings Aug 10, 2026 · consensus $-0.75 EPS, $2.04M rev
Last earnings +0.9% on 2026-05-12
Pre-product gene-medicine startup burning $112M/yr with ~1.7yrs cash and binary trial risk — a speculation, not an investment.
Cash & equivalents $189M · FY2025
Maze is a freshly public, clinical-stage genetics company whose value rests entirely on two early therapeutic candidates (MZE829 and MZE782) and its Compass target-discovery platform — none of which generate product revenue. The 1,916% jump in shares outstanding to 49.3M confirms a recent IPO, and the $168M of 'revenue' carried at FY2024 with $52.2M of net income almost certainly reflects a lumpy collaboration/license payment, not a recurring business: by FY2025 revenue is unavailable while the company swung to a -$131M net loss and a -$143M operating loss. The headline 8.5x P/S is therefore meaningless — it is priced off non-recurring collaboration income, not a sustainable top line.
The balance sheet looks superficially clean — $355M equity against just $42.2M of liabilities (0.12x), $350M current assets vs $22.6M current liabilities — but the number that matters is cash burn. Operating cash flow was -$112M and R&D rose 30% to $108M, against only $189M of cash and equivalents. That is roughly 1.7 years of runway with the burn rate still climbing, which all but guarantees a dilutive raise (or partnering on unfavorable terms) before the lead programs deliver pivotal data. Accumulated deficit already sits at -$490M.
| Line item | FY24 | FY25 |
|---|---|---|
| Revenue | $168M | — |
| Gross profit | — | — |
| Operating income | $57.6M | -$143M |
| Net income | $52.2M | -$131M |
| Diluted EPS | $1.25 | -$3.05 |
| Net margin | 31.2% | — |
Annual figures from SEC 10-K XBRL filings. Open the filing links below for full statement detail.
Computed from SEC XBRL annual figures + the current quote. EV and ROIC use long-term + current debt where filed; estimates, not investment advice.
Annual meeting results: directors elected, routine proposals passed
Officer/director change disclosed (Item 5.02)
Q1'26: continued R&D-driven losses funding MZE829/MZE782 trials
Q1'26: continued R&D-driven losses funding MZE829/MZE782 trials
Proxy: director slate, exec comp, auditor ratification for annual meeting
Other-events corporate/pipeline update disclosed (Item 8.01)
FY25 swung to $131M net loss; $189M cash backs clinical pipeline
FY25 swung to $131M net loss; $189M cash backs clinical pipeline
New debt facility entered, prior agreement terminated — adds obligation
Sources: SEC EDGAR (CIK 0001842295, latest 10-Q filed 2026-05-12) · EODHD · analysis by claude-code · as of 6/30/2026, 9:48:37 AM.
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Last 90 days: 0 open-market buys · 5 sales
| 2026-06-23 | Coloma Jason V Chief Executive Officer | Sell | 23.9K @ $26.05 | $622K |
| 2026-06-22 | Coloma Jason V Chief Executive Officer | Sell | 1.95K @ $26.00 | $50.8K |
| 2026-06-22 | Coloma Jason V Chief Executive Officer | Sell | 2.04K @ $26.00 | $53.0K |
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Dates from 8-K (Item 2.02); beat/miss = reported EPS vs consensus (Finnhub, recent quarters); move = prior close → close on/after.
1053 tracked peers · median
Recent news tone vs the market's typical (which skews positive). A soft signal, not a recommendation.